CLI Sperm Quiz

Blog written by CLI Compliance Officer Amy Erickson Hagen

1. What does IUI stand for?

Inter Uterine Insemination

2. In what year did scientists discover a technique for freezing sperm?

1949

3. What is the cryoprotectant that was initially used to protect sperm from damage during the freeze/thaw process and is still widely used today?

Glycerol

4. What is the name of the oldest commercial sperm bank?

CLI – founded in 1970

5. When did the FDA provide regulatory requirements for donor eligibility?

5/25/05

6. When was the first successful artificial insemination of a woman recorded?

1790 The renowned Scottish anatomist and surgeon, Dr. John Hunter, reported that he had successfully inseminated the wife of a linen draper, using her husband’s sperm.

7. Is a male born with all of the sperm he will ever have?

Unlike females who are born with all the eggs they will ever have in their ovaries, a male does not develop sperm until puberty. Sperm is then produced daily from puberty for the rest of his life.

8. What is the advantage of using frozen, quarantined sperm over fresh sperm?

Frozen sperm has been tested and quarantined then re-tested for various infectious diseases. There is significantly less risk of the female contracting an infectious disease using frozen, quarantined sperm.

9. What is the percentage of sperm donor accepted into CLI’s donor program?

1 in 200 so one half of one percent

10. What is the average conception rate for a fertile women using donor sperm per month?

15-20%. Very similar to the rate of natural conception.

Source: http://health.howstuffworks.com/pregnancy-and-parenting/pregnancy/fertility/sperm-bank.htm, http://en.wikipedia.org/wiki/Artificial_insemination.

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Donors are really nice guys

Blog written by Laboratory Staff JM

Sperm donors are typically a candid bunch of guys. Our lab staff interacts with the donors on a weekly basis, and we enjoy getting to know these men and why they have chosen to participate in a sperm donor program. While it’s true that the compensation factors into the decision for some donors, many donors really don’t care all that much about the financial reward and are more driven by a desire to help others. How do sperm donors feel about the contribution they make? Let me tell you some of the things I’ve been told by these really nice guys.

1. Sperm donors hope that the recipients of their samples are successful in their quest to have a family.

2. Sperm donors are compassionate and caring – an example: every so often we get a request to test one of our former donors for carrier status for a genetic disorder, by patient request. In my experience, the donors make every effort to come in for the testing. They usually say something like “I hope we get good news” or “Is the baby okay?”

3. We often ask them about their moms around the holidays (Christmas, Mother’s Day, etc). You can learn a lot about someone by the way he speaks about his mother. It’s touching to hear some of these men share their favorite memories about their moms, or hear that they are planning something special for their mom for a holiday surprise.

4. Some of our donors already have children of their own, and these donors in particular can appreciate the contribution they are making, because they know firsthand the joy of being a parent.

Learning what motivates a man to be a sperm donor is truly one of the most interesting aspects of working at a sperm bank. The decision to donate sperm is not one made lightly, and the reasons for doing so can vary. It is an honor to work in a field where you can see not only the impact the donors have on recipients, but also the impact being a donor has on the amazing guys who choose to donate sperm.

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Sperm Storage: Have You Wondered How Sperm Survive the Thaw?

Blog written by Director of Operations, Cryogenic Laboratories, Inc. Michelle Ottey, PhD. 

Most people do not think about long-term storage for sperm, but the people who work at sperm banks do.

Sperm is said to be able to be stored indefinitely. There have been successful pregnancies using sperm that has been store for almost 30 years.

How is this possible? When sperm is stored in Liquid Nitrogen (LN2), which has a temperature of -196° C, the cells are cryopreserved. Being cryopreserved means that there is no metabolic activity — the cells aren’t aging or degrading over time. The process of freezing and thawing the sperm cells will cause damage to the cells, which renders them unviable after the thaw.

When sperm cells are frozen, the crystallized water has the potential to damage the cell membrane, which is why a cryopreservative such as glycerol is used. The glycerol replaces the water in the cell and prevents this damage. Not all cells take in the glycerol uniformly and so not all cells will survive the freeze/thaw. When the cells are being thawed, the glycerol leaves the cell and is replaced by water, and many of the sperm will start swimming right along when they reach the optimal temperature.

The sperm freezing process may sound precarious, and it is. If sperm cells are maintained at temperatures lower than -135° C they will be stable. This requires careful monitoring of the temperature and liquid nitrogen levels in the tanks. Ideally tanks storing sperm should be monitored constantly, and there should always be an extra liquid nitrogen resource available to supplement the tanks if necessary.

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Top 5 Characteristics Used to Choose a Sperm Donor

Blog written by Director of Operations, Cryogenic Laboratories, Inc. Michelle Ottey, PhD.

When people are choosing a sperm donor they tend to know what they are looking for in that match. Thankfully, most sperm banks have a lot of information available to make the search easier.

1. Infectious and Genetic Testing

2. Ethnicity

3. Physical Characteristics

4. Education

5. Available Profile Information

Once an intended parent finds a sperm bank that demonstrates that they follow all of the required regulations to ensure the safety of their recipients, the search for the perfect sperm donor match becomes very personal. Some people want a sperm donor with their same ethnic background; others want a sperm donor who resembles a partner or family member. For others, a sperm donor’s education and talents are the most important factor.

When it comes down to it, finding the perfect donor match is finding a sperm donor who possesses characteristics that you would want to contribute to the creation of your child. There is a lot to consider, but the right sperm donor match is out there for you!

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The new PMS: Physically, Mentally and Spiritually

Blog written by Compliance Officer Amy Erickson Hagen

It is easy to look at our body, mind, spirit and emotions as if each part is fully separate from the other rather than totally intertwined. This fragmented approach can lead us to look at health in a compartmentalized manner rather than as the management of a whole self. Past medical teaching believed that our bodies, organs and systems are totally separate from our thoughts, emotions, energy fields and our spiritual selves. However recent thinking stresses the need to look at how our thoughts can affect our behavior and ultimately our health.

As I have said before, I am a science person, my mind just things that way. So I started out discovering more about my physical self. I would suggest reading Eat Right 4 Your Type or trying to think back to high school or college and remembering the 11 body systems. With conception we typically focus on the reproductive system (now you only have to think of 10 more) however the various other systems play an integral role in our overall health. If you have already become pregnant or are a parent you need full energy to be a parent so researching the physiology of the body won’t be waited time. I don’t consider myself a reader or really have the time to read about body systems so instead I would suggest just go online and search “11 body systems” and just refresh yourself. If something interests you then dig more.

As people being challenged with conception concerns, new parents or those changing our minds on how we view families, we need to understand how our emotions work and how various emotions can create illness in our bodies. We need to appreciate how our values and beliefs can directly affect our everyday health.

Personally I have turned to yoga and meditation to clear a path for the good in my life and clear negative energies. Does this always work, surely not, however it give me something of focus on other than daily frustrations. Someone recently told me to try to take care of yourself physically, mentally and spiritually instead of everyone or everything else and then the other stressors around you may appear different. So now, I ask myself daily PMS, what is the last thing I did to take care of myself physically, mentally and spiritually. If I can’t think of something I did recently for PMS then now is the time to do it.

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What’s in the Shape: Sperm Morphology (Part II)

Blog written by Laboratory Staff C.O.

Sperm morphology evaluation is a component of a complete semen analysis. Sperm cells are stained to make them visible, and several hundred are viewed under high magnification and scored individually as normal or abnormal based on their shape and size. The percentages of normal and abnormal shaped cells are calculated.

In a typical sample of a man considered to have a normal, healthy semen sample, we would expect to see more abnormal sperm cells than normal. There are several criteria currently used to evaluate sperm morphology; two of the more common criteria are the World Health Organization (WHO) and Kruger Strict.

WHO (Edition 4) criteria classify a sperm with borderline morphology (slightly abnormal) as normal. Based on these criteria men with 30% normal sperm are considered to have normal sperm morphology. WHO (Edition 5) states that men with 4% normal sperm are considered to have normal sperm morphology. This is a topic that elicits much discussion among the experts, and is rather controversial.

For Kruger Strict criteria, which is the method used by the Cryobank, sperm classified as borderline normal sperm are scored abnormal. Based on Kruger analysis men with 14% morphologically normal sperm are considered normal.

The shape of the sperm is a reflection of proper sperm development (spermatogenesis) in the testicles. Men with defective spermatogenesis may produce a high percentage of abnormal sperm. There are many factors that can lead to formation of abnormal sperm. The common ones are genetic trait (inherent), exposure to toxic chemicals, increased testicular temperature and infection. Nothing can be done if it is a genetic trait; however, the other causes may be reversible. Spermatogenesis takes place at a lower temperature than the overall body temperature. Anything that increases the testicular temperature e.g. wearing tight clothes that hold the testes close to the body will cause the production of abnormal sperm.

Cryogenic Laboratories, Inc. donors are evaluated for sperm morphology using Kruger Strict morphology. Any donor who does not pass the morphology analysis during the screening will not be admitted to the donor program.

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Getting to know your donor

Blog written by Laboratory Staff Zach K.

As part of my job as a laboratory technician, I work with donors on completing their personal profiles. Our donor profiles contain vast amounts of information about the donor and their family, almost down to their shoe size in detail. Not only do we get into the excruciating medical details but really try to get into the interests and family background of the donor. We do not do this solely to try and sell each donor but to really cater to our patients and provide those who are interested in our product with a diverse and well-rounded selection. We want our patients to feel a connection to the donor they are purchasing because their selection will have such an impact later on in starting their families. These selections could vary from a donor that came from a very religious background, someone who played sports throughout their life or maybe someone who is pursuing a masters or graduates degree (and of course many more options and combinations!).

While working with the donors on these profiles we get to know them along with the kind of life they had growing up. We get into the education and occupations of not only their parents and siblings but their uncles, aunts, and grandparents as well. This gives a wider picture of the type of environment and family the donor grew up around. The interest and hobbies of the donor are also very important to the profile process, these can include: the donor’s favorite songs, talents, personal achievements and awards.

The effort we put into completing these donor profiles really shows how dedicated we at CLI are to giving the highest quality of donor sperm and providing an easy and diverse selection process. Combined with the extensive genetic and disease testing, optional photos, optional I.D. option donors and many more donor selection aids, CLI truly tries to give the patient the most they can about each individual donor.

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The Fertility Forum Radio Show

CLI Director of Operations, Michelle Ottey, PhD was featured on The Fertility Forum radio show with Dr. Phyllis Martin. The Fertility Forum has professional guests in all areas relating to fertility. The topic of this show is all about sperm banks and sperm donors. You do not want to miss this great information!

Listen to the recorded show on The Fertility Forum website. The show can be found under Recent Shows, “Setting the Record Straight on Sperm Donation” dated October 3, 2011: http://toginet.com/shows/thefertilityforum

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Would you become a donor?

Blog written by Laboratory Staff Zach K.

As a man working in the sperm banking industry, I get asked many questions. Some of them weird, some of them random, but a majority of them are about our donor program and how you get in it. Usually at this point in the conversation I tell them about the strict criteria we have concerning medical history, phenotypes and specimen quality. I also tell them all of the testing and interviews our donors go through. But recently I was asked, “If you were hypothetically accepted into the donor program, would you do it?” I had never been asked that before and to be honest I had never even thought about it the entire time I have been with Cryogenic Laboratories, Inc.

Our donors are making a big decision by committing to this program. All of the testing, interviews, and blood draws aside, they know that their sperm will be used by those trying to create a family. This takes a very special kind of person to give this type of service to others. I think this is a testament to the type of men we recruit, test and eventually accept into our program. In fact I do not think I have ever heard one of our donors say the only reason they are in our program is because of the money.

I have always looked at our company through the eyes of the clients but never have I looked at it through the eyes of a donor. So to answer the question stated earlier, I believe that I would go into the program if I was accepted (hypothetically of course). Seeing the joy that can be brought to families and couples that use our services is priceless and to be a part of that would truly be an honor.

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A Sperm Bank Responds: Fairfax Cryobank and Cryogenic Laboratories, Inc.

An article was published last weekend on sperm donation which did not accurately reflect the way that sperm banks distribute sperm now or the way that we provide information to clients and their offspring. Every reputable sperm bank, for instance, adheres to the American Society for Reproductive Medicine’s (ASRM) guidelines for distribution of an individual donor’s sperm based on population genetics. Most sperm banks also have their own internal limits on donor production and distribution to avoid creating very large sibling groups.

In 2008, Fairfax Cryobank and Cryogenic Laboratories, Inc. (CLI) adopted a policy designed to limit each donor to producing 25-30 family units in the United States. To achieve this, we must rely on the patients to report their pregnancies and births to us so that we can accurately track the information and stop distribution of a particular donor when his family unit limit is met. Our reporting process is easy and can be done online, over the phone or via fax. We need our patients to report their pregnancies and births to ensure that we can accurately track the numbers for each donor.

As an additional way to limit the number of offspring, we calculate a ratio of the number of vials of Donor Sperm to pregnancies and limit the total number of vials a sperm donor can create. Once a family unit limit is met, the only units that can be distributed would be for sibling pregnancies so that patients can have children who are genetically full siblings to their previous child(ren.) These internal limits were the direct result of our management listening to the feedback from patients and offspring. We decided to limit the number of samples from each donor in order to limit the size of sibling groups. Unfortunately, some patients sell or give unused vials of sperm to others who wish to become pregnant if they no longer need the sperm, so we do not always know how many families are using a donor’s sperm because of this “gray market”, which makes our task somewhat more difficult.

Over the years, we have continued to add to the medical information we provide about to help patients choose their donor and to provide medical histories for offspring. Of course, an individual’s medical situation may change over time and we have implemented an easy to use system that allows our donors to login in to a secure website and update both their personal and family medical information. Our active donors understand when they start the Sperm Donor Program that we will follow up with them over time and stay in contact to continually update medical information. We have also made significant efforts to contact previous donors in order to obtain updated accurate medical information. We publish the updates on summary profiles. If anything of concern is discovered when we receive an update, including any issue that has the potential to affect offspring, we investigate and notify clients if it is necessary.

We recognize that offspring may want to know more personal details about their donor, and we provide profiles, audio interviews, photos, etc. The information available on Fairfax and CLI donors is extensive, and is probably more detailed than the information most people know about a good friend.

For people who want the option of personal contact with their donor, we offer ID Option donors. Patients now have the choice between Anonymous or ID Option donors. If the birth has been registered, the Fairfax Cryobank and CLI ID Option programs will release the information to the offspring when they reach 18 if they want to make contact. This is a guarantee. These ID release programs were not always an option in the past, but most sperm banks offer ID donors now.

We are committed to providing the very highest quality, best screened donor sperm possible so that individuals and couples faced with medical or social infertility can fulfill their dreams and build their families.

We advocate openness and disclosure of a child’s origins to the child regardless of a patient’s relationship status. It is widely accepted that disclosure happens more often with single mothers and lesbian couples than it does with heterosexual couples who have conceived via donor insemination (DI). We encourage all patients to disclose their child’s donor origin to the child. It has also been observed and is widely accepted that making the child’s donor conception part of their birth story from the beginning normalizes the experience. Fairfax and CLI have conducted annual surveys that will be presented at the ASRM annual conference in October. In these surveys the majority of our patients indicate that if they elect to disclose the child’s donor origin to the child, they do it before the child is 10 years old. Openness and disclosure will help to ensure that should half siblings meet accidentally, they will not partner romantically.

Fairfax Cryobank and CLI also recognize the desire of some recipients and offspring to make half sibling connections, and so we started our Family Forums. The forums provide a free, secure arena in which recipients with a registered birth can connect in a donor specific thread. They are guaranteed to be connecting with others who have used the same donor. Our forums are also a wonderful resource for information and updates about the donors. Working with the source, the sperm bank itself, is the only way to ensure verified and accurate information.

It is my opinion that the sperm banks, Fairfax and CLI specifically, actually are providing services that meet many of the goals stated by our most outspoken critics. It is through rational and informed discussion that positive change occurs. Flexibility, openness, education, science, and psychology are all necessary in making decisions about managing Sperm Banks and Sperm Donors. The progress that has been made, the change that has occurred, is rarely acknowledged by the critics; they reference the “industry” as it existed in the past without referencing accurate procedures of the present. Although they used donors they knew were anonymous to build their families, some of these critics of the donor sperm banks are trying to hunt down the very same men who gave them the gift of a family, although they know that these men intended to remain anonymous. They want the sperm banks that promised anonymity to these men to break that promise, which we will not do, just as we do not break our commitment to patients.

The missions of Fairfax Cryobank and Cryogenic Laboratories, Inc. are based on the fundamental desire to provide the highest quality donor sperm from the most rigorously screened sperm donors to patients in order to build healthy families. Tens of thousands of children have been born through DI and that number is growing every day. If anyone believes that the mission of our Cryobanks is self-serving or simply to “make money and get people pregnant” they are mistaken. We work, every day, to make it possible for people to build their families. We are committed to serving our patients with compassion, knowledge, and openness. We are open to change and have demonstrated this through the evolution of our internal procedures. We are also open to fair and rational discussion in order to further our mission.

Michelle Ottey, PhD                                                                                                                       Director of Operations                                                                                                              Fairfax Cryobank and Cryogenic Laboratories, Inc.

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